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Transcriptomic analyses have highlighted differentially expressed genes, alternative splicing, and regulatory pathways involved in physiological adaptations

GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

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It's also a potent detoxification agent, helping our bodies eliminate everything from heavy metals to environmental toxins and the byproducts of our own metabolism

Furthermore, a study in 2021 demonstrated that propofol can reduce myocardial ischemia/reperfusion (I/R) injury by activating the PKC/ NRF2 pathway in H9C2 cells and the rat Langendorff model [44]